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Comprehensive profiling of transcriptional networks specific for lactogenic differentiation of HC11 mammary epithelial stem-like cells

15:11 06 August in Uncategorized

The mammary gland is an apocrine gland, and its crucial function is to produce and secrete milk. The essential components of the adult mammary gland are alveoli, which are lined by milk-secreting epithelial cells. Myoepithelial cells and a stromal compartment that are derived from embryonic...

High coverage genome sequencing and identification of genomic variants in Bengal tiger (Panthera tigris tigris)

17:37 11 May in de novo genome sequencing, Genome Assembly, Sequencing

India's renowned genomics and bioinformatics company Nucleome Informatics, annouces the succesful completion of Indian Bengal tiger genome sequencing in collaboration with LaCONES, CCMB, Hyderabad. Panthera tigris tigris, one of six extant tiger subspecies, occurs solely in the Indian subcontinent. Although endangered and threatened by various extinction...

Deep sequencing of small RNAs reveals ribosomal origin of microRNAs in Oryza sativa and their regulatory role in high temperature

16:24 04 May in miRNA Sequencing

MicroRNAs are small noncoding regulatory RNAs which control gene expression by mRNA degradation or translational repression. They are significant molecular players regulating important biological processes such as developmental timing and stress response. We report here the discovery of miRNAs derived from ribosomal DNA using the...

RNA sequencing of murine mammary epithelial stem-like cells (HC11) undergoing lactogenic differentiation and its comparison with embryonic stem cells

16:35 11 April in RNA Sequencing

Understanding of transcriptional networks specifying HC11 murine mammary epithelial stem cell-like cells (MEC) in comparison with embryonic stem cells (ESCs) and their rewiring, under the influence of glucocorticoids (GC) and prolactin (PRL) hormones, is critical for elucidating the mechanism of lactogenesis. In this data note,...